doi: 10.1021/acscentsci.9b01063 28 LeeHZandkarimiFZhangYMeenaJKKimJZhuangLet al
Key Features Defined Tetrapeptide Sequence (Ala-Glu-Asp-Gly) What it is: The exact, unaltered chain of four specific amino acids
We often have some data on a single peptide (or at least a plausible mechanism), but very little high-quality human evidence that stack A + stack B produces additive benefitor does so safely
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Conditions or therapies that predispose patients to acidosis, such as kidney disease, severe pulmonary disease, status epilepticus, diarrhea, ketogenic diet, or certain drugs, may be additive to the bicarbonate lowering effects of topiramate
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