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GPX4 is an enzyme that can directly reduce LOOH to harmless lipid alcohol (LOH), which can inhibit the accumulation of lipid ROS

(2016) were the first to demonstrate that transplanting fecal matter from PD patients into mice genetically engineered to overexpress alpha-synuclein significantly worsened their motor symptoms compared to mice receiving transplants from healthy human donors

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The message was clear: evidence generation does not end when a therapy receives regulatory approval