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In two mouse models, CICB was associated with intestinal inflammation characterized by upregulation of Il1b , but not Tnfa or Il6

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Diabetes 45:16261630 Fernandez-Alvarez J, Conget I, Rasschaert J, Sener A, Gomis R, Malaisse WJ (1994) Enzymatic, metabolic and secretory patterns in human islets of type 2 (non-insulin-dependent) diabetic patients

While these platforms are attractive in terms of safety, speed, stability and scalability, they carry a significantly higher risk of failure in clinical development as seen previously with other novel technologies 40

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