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Perlecan, a prominent heparan sulfate proteoglycan in BM, is crucial in BBB maintenance and repair, particularly in pericyte interactions following brain injuries like ischemic strokes [70,71,72]

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The three chemicals are the active ingredients in drugs made by Novo Nordisk and Eli Lilly for weight loss and diabetes, including Wegovy, Ozempic, Zepbound and Mounjaro, but because there is no shortage of them the agency is leaving them off the list, the FDA said in a press release

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Baughman, H