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Binding of an RNA aptamer and a partial peptide of a prion protein: crucial importance of water entropy in molecular recognition

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suggests that, while normal, IGF-1 appears to bind readily to IGF-binding proteins

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Enhanced with the substitution of an Arginine for the third position of its amino acid sequence and an extension peptide at the N-terminus, IGF-1 LR3 is designed to boost the biological activity of the IGF hormone

doi: 10.1007/s00251-017-1017-3 87 YasukochiYSattaY