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At 10mg The 10mg dose represents a significant inflection point for GI side effects generally, and heartburn specifically

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This includes people with: High potassium levels in the blood Known hypersensitivity to the drug Addisons disease, or adrenal insufficiency, since it may cause potentially hazardous high blood potassium and low blood pressure Spironolactone also should not be taken in combination with the drug Inspra (eplerenone)