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What the Newer Nondiabetic Data Found A JAMA Ophthalmology cohort study published in late 2025 looked at adults aged 55 or older with overweight or obesity but without diabetes

The recommended starting dose is 2.5 mg weekly for at least 4 weeks before increasing it to 5 mg

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Store in a cool & dry place in an airtight container

Why people switch The most common reasons include weight loss plateaus, inadequate response at maximum dose, side effect intolerance, cost or insurance changes, and desire for greater efficacy

Lifestyle modification, including medical nutrition therapy and increased physical activity, is the key pillar in the treatment of obesity ( Table 1 ) ( 2 and obesity-related comorbidities such as hypertension, type 2 diabetes and sleep apnea, mark the beginning of a new era in obesity treatment ( Table 1 Currently approved and available weight loss drugs