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However, human safety data beyond 12 weeks doesn't exist

The highest levels of cytochrome P450 can be found in the endoplasmic reticulum of cells found in the liver and gastrointestinal tract, with the liver serving as the major site for phase I CYP metabolism

Medical knowledge evolves continuously, and information that is current at time of publication may become outdated as new research emerges

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Results Protection from alcohol-induced steatosis and accelerated clearance of ethanol and acetaldehyde in KO mice Mice were fed a high fat liquid diet containing ethanol (EtOH) or isocaloric control (CON) diet for 6 wk