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Another drug, ES2, targets FOXO4 conserved region 3 (CR3) but has a significantly lower selectivity than FOXO4-DRI 25

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Biomarkers tested Vitamin D level Inflammatory markers Bone density scan (DEXA) Insulin-like Growth Factor 1 (IGF-1) Sex hormone levels Treatments offered Long term benefits Improved bone density Lowering the risk of osteoporosis Preservation of muscle mass Improved joint function Reduced pain Better mobility Better physical activity Cognitive decline starts years before symptoms

Uncommon (1-10 in 1,000 people): itching rash, dizziness, diarrhea

Aged animals typically show significant deficits on these tasks due to progressive synaptic loss and reduced neuroplasticity

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