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Records indicated that the severity of a patients condition played a role: Those with diabetes and obesity were more likely to fill prescriptions than patients with diabetes only, who were more likely to fill than those with obesity only

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FSEN1 was identified as a small-molecule inhibitor of FSP1 through chemical screening 118 , and subsequent structural analyses revealed that FSEN1 occupies the substrate-binding pocket of FSP1 in a position analogous to CoQ observed in the enzyme active site, providing structural insight into inhibitor recognition 119

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