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Unfortunately, many people are vitamin B12 deficient, especially those who follow a vegetarian or vegan diet

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However, this adaptive mechanism may not be sufficient to counteract the overwhelming oxidative burden caused by iron overload ( Moreover, the use of antioxidants has been explored as a potential therapeutic strategy to mitigate oxidative stress in thalassemia patients

Regular B12 screening is recommended, especially for those on Metformin for over four years

[DOI] [PMC free article] [PubMed] [Google Scholar] 223.Mazure NM, Chen EY, Yeh P, Laderoute KR, Giaccia AJ

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