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Von Frey testing showed a notable reduction in paw withdrawal thresholds in the OA model mice (Fig

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This is supported by translational data indicating that blocking nitro-oxidative stress, inflammatory and neurotoxic pathways with selective antioxidative compouds may alleviate depressive-, anxiety-, and chronic fatigue-like behaviors [25, 26, 30, 35,36,37,38,39,40]

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