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The review revisited SUSTAIN-6, where semaglutide-treated patients showed a hazard ratio of 1.76 for retinopathy complications compared with placebo. The discussion has since shifted toward whether rapid metabolic changerather than direct retinal toxicitymay explain the signal

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When given in higher doses, however, nausea became more pronounced

You may also begin to notice changes in your appetite and weight

New GLP-1 medications are entering the market

First discovered in distal intestinal peptide YY (PYY)-containing EECs 95 , neuropod cells in the intestine can sense sugars and transduce a signal to the brainstem within milliseconds via a single synapse 96