The most common metformin-related side effects are gastrointestinal including diarrhea, abdominal pain, bloating, nausea, and loss of appetite
By Lana Pine | Published on June 19, 2025 4 min read People with diabetes who take glucagon-like peptide-1 (GLP-1) receptor agonists (such as Ozempic and Wegovy) may have more than twice the risk of developing a serious eye condition called neovascular age-related macular degeneration (nAMD) a leading cause of vision loss in older adults according to a large-scale study published in JAMA Ophthalmology
Nausea and reduced appetite are among the most frequently reported side effects of GLP-1 medications, particularly during the initial weeks of treatment or following dose increases
Additionally, compound 49 showed good COX-2 inhibitory activity
With the market for GLP-1 drugs predicted to exceed $100 billion by 2030, the pharmaceutical companies have been jostling for industry supremacy and are taking on businesses that they believe are encroaching on their sales and brand names
Cycling off periodically may help maintain sensitivity and response