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In rodents, non-shivering thermogenesis is mediated by the uncoupling protein-1 (UCP-1) in brown adipose tissue (51)
The incidence of acute pancreatitis, as confirmed by post-marketing monitoring data, are less than 0.1%, which is in line with the rates seen in the general diabetic population
Importantly, this increased GCG receptor activity did not adversely impact glycemic control
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Clinical trials have shown that discontinuing treatment typically results in gradual weight regain and worsening glycemic control, underscoring that these are chronic disease management tools rather than short-term interventions