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Limitations The principal limitations are related to the fact that we analyzed means from the RCTs instead of individual patient-related data

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Moreover, large-scale clinical trials have demonstrated that the GLP-1 receptor agonist semaglutide reduces the risk of cardiovascular and renal events, underscoring the clinical importance of the GLP-1 pathway 8,9

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Heart rate increased by a mean of 3-4 bpm, consistent with the GLP-1 class effect