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Handling dose escalation side effects The transition periods, especially from 2mg to 4mg and from 4mg to 8mg, are where most side effects occur

The Lancet 368(9548):16961705 Popoviciu MS, Pduraru L, Yahya G, Metwally K, Cavalu S (2023) Emerging role of GLP-1 agonists in obesity: a comprehensive review of randomised controlled trials

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Similarly, knowing the best foods to eat on semaglutide supports both weight loss and nutritional adequacy

Individuals can make their own risk/reward analysis

Gallwitz B, Rosenstock J, Rauch T, Bhattacharya S, Patel S, von Eynatten M, Dugi KA, Woerle HJ: 2-year efficacy and safety of linagliptin compared with glimepiride in patients with type 2 diabetes inadequately controlled on metformin: a randomised, double-blind, non-inferiority trial