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In hepatocytes from mice in which the TKT gene was knocked out there is an accumulation of ribose-5-phosphate as well as the nucleotides, inosine, adenosine, and deoxyadenosine

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instead, they work in fundamentally different ways

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In Advances in Medicinal Chemistry

Unlike the transketolase used in the last reaction, the transaldolase enzyme does NOT use TPP as a cofactor