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While hydroquinone was once an OTC option, the FDA has reined in the controversial benzene derivative, making it prescription-only in the United States as of September 2020

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Members emphasised that although certain conclusions may be reached regarding novel formulations in general, it is key to assess specific active compounds and their formulation on a case-by-case basis

They also include vitamin C, hydrolysed collagen, hyaluronic acid, CoQ10, zinc, biotin and selected supporting ingredients