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Scientists engineered this analog by replacing the third amino acid (glutamic acid) with arginine and adding a 13-amino-acid extension peptide to its N-terminus

First, antihistamines don't address the root cause mast cell activation continues, and histamine keeps building up

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Pentadeca Arginate (PDA) is simply the chemical name for this exact same 15-amino-acid sequence, with the Arginate referring to the salt form its bound to for enhanced stability and solubility

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A landmark study published in the journal Amino Acids investigated its role in allergic responses and found that theanine successfully inhibited systemic anaphylactic shock and tissue swelling in animal models