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Moffatt O, Drury S, Tomlison M, Afnan M, Denny S

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Novo Nordisk successfully completes AM833 phase 2 trial and phase 1 combination trial with AM833 and semaglutide in obesity (2020)

In addition, circUtrn functions as a molecular sponge for microRNA-195-5p (miR-195-5p), a pro-apoptotic microRNA known to suppress anti-apoptotic genes such as F-box and WD repeat domain-containing protein 7 (FBXW7) and Mitofusin 2 (MFN2) (204)

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Consistently with a mechanism involving mitochondrial uncoupling, HC-treated cells showed a m drop comparable to that observed in CCCP-treated cells