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2 The main sources of cellular ROS are mitochondria and nicotinamide adenine dinucleotide phosphate (NADPH) oxidases, and peroxisomes containing xanthine oxidase and the inducible form of nitric oxide synthase, which produce superoxide anion and nitric oxide, respectively

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Decreased expression of GSH synthesis leads to low free GSH levels, resulting in elevated ROS, immune dysfunction, and increased disease severity in COVID-19 patients 592

Water retention via enhanced sodium reabsorption manifests as rapid weight gain and potential blood pressure elevation