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Ethics declarations Competing interests SJW is the founder of Ridgeline Therapeutics, HN is a paid employee of Ridgeline Therapeutics and, since manuscript submission, ADW has also become a paid employee of Ridgeline Therapeutics

Studied in models involving NNMT activity, NAD+-related biology, and metabolic pathway regulation

[126] Cellular reprogramming [edit] Vitamin B 12 through its involvement in one-carbon metabolism plays a key role in cellular reprogramming and tissue regeneration and epigenetic regulation

Hydroxocobalamin might stay in the body longer

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Age and Sex of Subjects: These are often overlooked but incredibly important