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Dempsey said, It was pretty mind-boggling to see the response and the fact that it was global, it was systemic, and pretty quick

In 2022, some of the top-selling drugs in this category were Novos Ozempic (US$ 8.7 billion), Lilly and partner Dainippon Sumitomos Trulicity (US$ 7.7 billion), Novos Victoza (US$ 1.8 billion), and Rybelsus (US$ 1.6 billion)

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Importantly, none of the trials in T1D reported an increase in diabetic ketoacidosis (DKA) a key concern that has limited the use of SGLT2 inhibitors in T1D

Collectively, these observations support the benefits of calorie restriction and heighten the interest in pharmacologic agents, such as metformin, as calorie restriction mimetics