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CJC-1295 is a modified GHRH analog that activates the complementary GHRH receptor pathway in the pituitary

The increased internal Ca 2+ can, in turn, promote release of glutamate in synapses, forming a vicious cycle that aggravates destruction of nerve tissue

[DOI] [PMC free article] [PubMed] [Google Scholar] 110.Caracci M.O., Avila M.E., Espinoza-Cavieres F.A., Lopez H.R., Ugarte G.D., De Ferrari G.V

Studies have suggested that higher doses might become necessary for significant health advantages, but they should be taken under medical supervision