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While this observational study cannot prove causation, it raises important questions about whether GLP-1s could become part of future strategies for substance use disorders, overdose prevention, and post-overdose care management

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Appetite loss actually begins within hours for some patients and is the intended therapeutic responseit signals that semaglutide is activating the right pathways

Exposure to canonical ferroptosis inducers, including erastin, RSL3, and glutamate, triggers a rapid loss of mitochondrial membrane potential (m), thereby impairing oxidative phosphorylation and compromising respiratory ATP production [101, 102]