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Moreover, the activation of MAO-A also suppresses the expression of the mitochondrial function regulator PGC-1, exacerbating mitochondrial dysfunction, thereby promoting the phenotypic changes of ECs towards atherosclerosis and the progression of atherosclerotic disease (Li et al., 2021)

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The following considerations further strengthen the criticism toward the use of PAC as a safer alternative to NSAID: PAC has been preferred to NSAIDs and steroids for the symptomatic and domiciliary management of the early stages of COVID-19, a choice grounded of the precautionary principle (but still theoretical in this specific case) principle primum non nocere (Micallef et al., 2020a)

Association of gamma-glutamyl transferase with subclinical coronary atherosclerosis and cardiac outcomes in non-alcoholics

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Frhlich E, Wahl R