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In muscle tissue, transamination of BCAAs yields glutamic acid, which in turn contributes anaplerotic substrates (such -ketoglutaric acid) to the Krebs cycle, while simultaneously generating NADH to fuel mitochondrial respiration 16

Caution is advised when combined with ACEinhibitors, as DSIP is rapidly degraded by aminopeptidases Potential side effects include injection site irritation, headache, vivid dreams, and hormonerelated effects

Research is underway to develop therapeutics based on the properties of LL-37

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Introduction to Peptide Synthesis

Hauser DN, Hastings TG