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Placebo-controlled cross-over trial in patients with T2DM and albuminuria that shows that liraglutide therapy reduces 24-h urinary albumin excretion by lowering blood pressure, rather than by improving HbA 1c levels and body weight
Importantly, LBM remained largely stable, with slight gains in leg and arm FFM in some patients, resulting in minimal changes in skeletal muscle index and no cases of sarcopenia
Healthy fats may contribute to meal-stimulated GLP-1 responses, though evidence for specific fat types (like omega-3 fatty acids and monounsaturated fats) having direct GLP-1 effects is mixed and modest
One unanswered question is whether long-term use could lead to reduced responsiveness over time
The Low and Slow Titration Schedule Standard titration increases the dose every four weeks