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Cardiac and Renal Considerations Due to the glucagon component, some participants experienced a transient increase in heart rate during the first few months of treatment

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Myocardial expression of CC- and CXC-chemokines and their receptors in human end-stage heart failure

Li J, Wang J, Chen Z

Receptor Occupancy Across the Dosing Cycle Receptor-occupancy modeling from Eli Lilly's Phase I data shows that at steady-state 15 mg dosing, trough plasma concentrations maintain greater than 80% GLP-1R occupancy and greater than 70% GIPR occupancy in beta-cells [28]

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