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This capacity comes in part from the fact that their small size allows them to pass through the skin as well as through the blood-brain barrier

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Cell 161: 215227 HajduCronin YM, Chen WJ, Patikoglou G, Koelle MR, Sternberg PW (1999) Antagonism between G(o)alpha and G(q)alpha in Caenorhabditis elegans : the RGS protein EAT16 is necessary for G(o)alpha signaling and regulates G(q)alpha activity