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Early-stage research suggests intranasal dihexa may achieve therapeutic CNS concentrations with minimal systemic exposure, potentially extending the effective half life at the target site (hippocampus) while reducing plasma half life

[DOI] [PubMed] [Google Scholar] Castelli MC, Wong D, Friedman K, Bhargava P, Riley GM

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These studies have generally demonstrated positive therapeutic outcomes, but translation to clinical applications requires careful consideration of species differences and experimental limitations

The link between COVID-19 vaccinations and Sneddon Wilkinson Disease (Sneddon Syndrome) is one such worry that has drawn attention