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Tricyclic NNMT inhibitors (e.g., Ruf 2022 series) occupy different binding modes and scaffolds used primarily in drug-discovery lead optimisation
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Its non-hormonal nature sets it apart from other treatments, ensuring that it does not interfere with the bodys endocrine system
These include fortified breakfast cereals, plant-based milk alternatives (soya, almond, oat), nutritional yeast, and some meat substitutes
As a result, plasma concentrations of topiramate may be markedly higher soon after dosing and subtherapeutic later in the day
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