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Improve Nutrient Density, Not Portion Size Since appetite is reduced, each meal should provide more nutrition per bite

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While dehydration itself is not typically reported as a direct side effect in clinical trials, the risk stems from the common gastrointestinal side effects that can lead to fluid loss

The predicted weight reduction for each cohort was then used to predict the effect sizes for the primary endpoints in the OSA and OA baskets independently, acknowledging that this approach could underestimate weight lossindependent or drug mechanismdependent effects, which may additionally contribute to efficacy

Any deviation from licensed dosing regimens should only occur under close medical supervision, as the risk-benefit profile at sub-therapeutic doses remains poorly characterised

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