soul trial oral semaglutide cardiovascular outcomes 2024 nejm Long-term kidney of in obesity and disease in the SELECT Emily Kronau, PharmD, MBA (@Phar_em_D)

Abbreviations ABC: ATP-binding cassette (transporter superfamily) ABCB6/7/8/10: ATP-binding cassette subfamily B member 6/7/8/10 (mitochondrial/inner-membrane transporters) AEC-II: Type II alveolar epithelial cell AI: Artificial intelligence APP: Amyloid precursor protein ARE: Antioxidant response element ATP: Adenosine triphosphate BAX: Bcl-2associated X protein BBB: Bloodbrain barrier Bcl-2: B-cell lymphoma 2 BDNF: Brain-derived neurotrophic factor BPD: Bronchopulmonary dysplasia CKD: Chronic kidney disease CRISPR: Clustered regularly interspaced short palindromic repeats (genome editing system) CSF: Cerebrospinal fluid DANCR: Differentiation antagonizing non-protein coding RNA DC: Dendritic cell DIC: Disseminated intravascular coagulation DLCO: Diffusing capacity of the lung for carbon monoxide DNA: Deoxyribonucleic acid DOX: Doxorubicin EBV: EpsteinBarr virus EMA: European Medicines Agency EV / EVs: Extracellular vesicle(s) FDA: (U.S.) Food and Drug Administration GDNF: Glial cell linederived neurotrophic factor GFR: Glomerular filtration rate GPX: Glutathione peroxidase GPC1: Glypican-1 H2O2: Hydrogen peroxide hAEC-EVs: Human amniotic epithelial cellderived extracellular vesicles HIF-1 : Hypoxia-inducible factor-1 alpha HIV: Human immunodeficiency virus HIE: Hypoxicischemic encephalopathy HPV: Human papillomavirus HSFs: Heat shock factors HSP / HSP70/HSP72: Heat shock protein(s) / 70-kDa family / inducible 72-kDa form IKK: IB kinase IL: Interleukin IL-1 : Interleukin-1 beta IL-1RA: Interleukin-1 receptor antagonist IL-6: Interleukin-6 IL-10: Interleukin-10 ISEV: International Society for Extracellular Vesicles iPSC(s): Induced pluripotent stem cell(s) LNP(s): Lipid nanoparticle(s) MALAT1: Metastasis-associated lung adenocarcinoma transcript 1 MAPK: Mitogen-activated protein kinase MEVs: Milk/breast-milkderived extracellular vesicles MET: Mesenchymalepithelial transition factor (c-MET) miRNA(s): MicroRNA(s) MISEV: Minimal Information for Studies of Extracellular Vesicles (ISEV guidelines) MOF(s): Metalorganic framework(s) mRNA: Messenger RNA MPTP: Mitochondrial permeability transition pore MRP1/2/7: Multidrug resistance-associated protein 1/2/7 (ABC transporters) MSC(s): Mesenchymal stem cell(s) MSC-EVs: Mesenchymal stem cellderived extracellular vesicles NAC: N-acetylcysteine NEC: Necrotizing enterocolitis NF- B: Nuclear factor kappa-light-chain-enhancer of activated B cells NMPA: National Medical Products Administration (China) NRF1/NRF2: Nuclear respiratory factor 1/2 (mitochondrial biogenesis regulators) Nrf2: NF-E2related factor 2 (antioxidant master regulator) OMV(s): Outer membrane vesicle(s) PCL: Polycaprolactone PGC-1 : Peroxisome proliferator-activated receptor- coactivator-1 alpha PEG: Polyethylene glycol PI3K/Akt: Phosphoinositide 3-kinase / protein kinase B pathway piRNA(s): PIWI-interacting RNA(s) PLGA: Poly(lactic-co-glycolic acid) PPAR : Peroxisome proliferator-activated receptor gamma PTEN: Phosphatase and tensin homolog RDS: Respiratory distress syndrome RNA: Ribonucleic acid ROS: Reactive oxygen species SAPN(s): Self-assembling peptide nanovaccine(s) SARS-CoV-2: Severe acute respiratory syndrome coronavirus 2 siRNA(s): Small interfering RNA(s) SOD: Superoxide dismutase STAT3: Signal transducer and activator of transcription 3 STING: Stimulator of interferon genes TFAM: Mitochondrial transcription factor A Th1/Th2/Th17: T-helper cell subsets 1/2/17 TGF- : Transforming growth factor beta TLR-4: Toll-like receptor 4 TNF- : Tumor necrosis factor alpha Treg: Regulatory T cell USP14: Ubiquitin-specific peptidase 14 VEGF: Vascular endothelial growth factor VLP(s): Virus-like particle(s) WHO: World Health Organization A

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Your commitment tier determines your access level and support frequency, but your monthly cost remains flat regardless of whether you dose at the lower or higher end of your therapeutic range

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