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doi: 10.1016/j.lfs.2019.03.001 22 DAngeloS.ScafuroM.MeccarielloR

A study by Mondragon et al

Effects of erastin on human prepuce fibroblast BJeLR cells were primarily focused on the alternations in mitochondrial morphology and cristae structures, including mitochondrial atrophies, increased membrane density, the reduction or even extinction of mitochondrial cristae, and the outer mitochondrial membrane (OMM) rupture

NNMT is overexpressed in adipose tissue and various cancer cell lines, and its inhibition has been studied as a strategy to increase intracellular NAD+ levels, enhance one-carbon metabolism, and reduce adipogenesis in preclinical models

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