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Although demyelination induced by ICIs should be promptly diagnosed and treated according to the guideline for each specific disease (e.g., MS), prescription of GLP-1RAs might be efficacious for the nirAE as a concomitant therapy with immunosuppressors (corticosteroids, intravenous immune globulin, plasmapheresis, etc ) (Rajendram et al., 2021)
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Also, GLP-1 RA seems to regulate glucose homeostasis by exhibiting glucagonostatic effects meaning suppression of glucagon by acting on pancreatic cells, which in turn reduce hepatic production of glucose (52)
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