A growing body of literature suggests other tissues outside the brain, including the liver, can also influence the development and progression of AD 91,92,93
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It steps in to neutralize free radicals , converting them into harmless molecules that can be safely eliminated from the body
Patients may experience: Sensory symptoms : Burning pain, sharp or shooting sensations, increased sensitivity to touch (allodynia), or reduced ability to feel temperature changes Motor symptoms : Muscle weakness, loss of coordination, difficulty walking, or foot drop Autonomic symptoms : Changes in blood pressure, heart rate irregularities, digestive problems, or abnormal sweating Many patients describe the discomfort as worse at night, which can significantly impact sleep quality and overall well-being
Compared to the combination of sertraline with artemether, the combination of sertraline and chloroquine showed a stronger synergy with less toxicity to PHGDH wild type cells
Further investigations are now needed to illustrate the modulatory mechanisms and effects of DPP-4i on BP
