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Sirtuins are enzymes dependent upon NAD+ and play pivotal roles in cellular function, including DNA repair and metabolic pathways

P450 enzymes are involved in the metabolism of a wide range of compounds, including drugs, steroid hormones, fatty acids, and bile acids

It was believed by the research team that concentrations of B12 would increase with age

The Origins of Glutathione Peroxidase 4 GPX4, initially called phospholipid hydroperoxide glutathione peroxidase (PHGPX), was first purified in 1982 by Ursini et al

As such, we recruited 102 sex-matched sibling pairs who were discordant for konzo from the Kahemba region of DRC

doi:10.1038/288715a0