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Am J Physiol 1991

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96 Increased serum levels of GH and IGF1 have been observed in type 2 diabetes mellitus (T2D) patients with proliferative diabetic retinopathy compared to T2D patients with nonproliferative retinopathy or with no evidence of this complication

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The charged residues like glutamic acid, lysine, and the two aspartic acids enable specific interactions with cellular receptors and signaling molecules

These newly proposed mechanisms also help to explain the biosynthesis of isocereulides A ( 2 ) to G ( 8 )