Other considerations documented for tirzepatide in its FDA labeling include injection-site reactions, decreased appetite, and warnings such as the risk of thyroid C-cell tumors observed in rodents (a boxed warning) and pancreatitis and gallbladder events
Talk to your doctor if you have a history of liver or kidney diseases and if you are pregnant or breastfeeding
De Logu, F
The article points to people with borderline B12 levels, gastrointestinal disorders, or limited dietary B12 intake as better candidates for the combined formulation
Beyond glycemic control, GLP-1 receptors are distributed throughout the body, including in the central nervous system
paracasei evoked vagal firing in colonic tissue with an intact epithelium, which may be mediated through activation of GLP-1Rs on L-cells leading to basolateral secretion of GLP-1 and subsequent activation of vagal afferents (Bohrquez et al., L