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Early-phase human trials are small, well-controlled studies centered on safety, reproductive hormones, and surrogate markers such as ovarian reserve tests and sperm parameters ahead of any efficacy trials

Reported influences on growth-factor signaling and inflammation resolution in animal or ex vivo models

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Inflammation causes tryptophan to be reallocated from serotonin synthesis to that of kynurenine, which then converts to the neurotoxin quinolinic acid, leading to depression

A critical area for research is the extent of the anticancer effects and apoptosis induction by curcumin

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