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Ideally, that medical supervision would be from an obesity medicine specialist, an expert who goes through a specific medical fellowship to help people lose weight and keep it off, says Pinto

J Clin Psychopharmacol 2015;35:486-9

Many of them work by targeting GLP-1

Users consistently report approximately 60 percent better outcomes compared to either peptide alone, a finding that aligns with their complementary mechanisms

According to Mayo Clinic, they can also cause a person to sweat less, which could inhibit their ability to cool off and may actually raise body temperature

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