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The presence of PD-L1 on LECs induces T cell tolerance through PD1/PD-L1 interaction and lack of co-stimulation (98), thus restricting CD8+ T cell activation and reducing their accumulation in the tumor microenvironment (95)

Glucagon-like peptide type 1 receptor agonistsIncretin effect and systemic effects of glucagon-like peptide type 1 and its agonists The incretin effect describes the phenomenon whereby oral glucose elicits higher (23 times) insulin secretory responses than does intravenous glucose.25 This is due to incretin hormones, such as GLP-1 or glucose-dependent insulinotropic polypeptide, which stimulate insulin secretion in response to food intake

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