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Glucocorticoids, including cortisol, can regulate MMP-9 (79), therefore, it is possible that this negative relationship is related to chronic cortisol dysregulation in PTSD

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Fructose-1,6-bisphosphatase inhibits the activity of HIF-1 in the nucleus, decreases the expression of HIF target genes, and promotes its degradation by binding to Notch1, regulating tumor formation

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