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This creates S-adenosylmethionine (SAM), which works as the universal cofactor for most biological methylation reactions [19]

[1] In cultured mouse adipocytes, exposure to a methylquinolinium NNMT inhibitor raised intracellular NAD+ and SAM and lowered lipogenesis

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Results of a small, open-label (not placebo-controlled) study of PS128 showed that PS128 supplementation for 12 weeks in addition to anti-parkinsonian medication improved United Parkinson Disease Rating Scale (UPDRS) motor score and quality of life