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The laboratory studies suggest severe iron poisoning as evidenced by the drop in bicarbonate and arterial pH (metabolic acidosis as iron becomes hydrated and poisons the mitochondria), the rise in aminotransferases, fall in albumin, rise in prothrombin time and INR, and rise in total and conjugated bilirubin (liver failure) 4

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Tolerance to the anorexiant effects of phentermine usually develops within a few weeks of starting therapy