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From myocardial I/R injury to DCM, atherosclerosis, and HF, cuproptosis mediates pathogenic processes through mechanisms including mitochondrial dysfunction, proteotoxic stress, GSH depletion, and lipid metabolism disruption

Proc Natl Acad Sci U S A 95:30716, PMID: 9501217 Won HY, Sohn JH, Min HJ, Lee K, Woo HA, Ho YS, Park JW, Rhee SG, Hwang ES (2010) Glutathione peroxidase 1 deficiency attenuates allergen-induced airway inflammation by suppressing Th2 and Th17 cell development

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Numerous health conditions are characterized by low levels of glutathione, particularly those associated with aging and cognitive decline

[DOI] [PMC free article] [PubMed] [Google Scholar] 20.Li C, Sun G, Chen B, Xu L, Ye Y, He J, Bao Z, Zhao P, Miao Z, Zhao L, Hu J, You Y, Liu N, Chao H, Ji J