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Malaguarnera, M., et al

Pretreatment with metformin protects mice from whole-body irradiation

The 4-week hold at each step gives the drug time to plateau before adding more

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Topical application uses 1-2% concentration in serums applied daily

Acetaminophen-induced oxidant stress and cell injury in cultured mouse hepatocytes: protection by N-acetyl cysteine