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The EV isolation and characterization aligned with the minimal information for the study of extracellular vesicles 2018 checklist 152

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Participants in both groups were permitted to continue taking multi-vitamins, probiotics, and other medications/supplements as long as they were not those mentioned in the exclusion criteria (i.e., known to significantly raise glutathione levels)

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Since it can bind to cells if the pO 2 levels are less than 10 mm Hg, Hypoxyprobe-1 is used as a probe for intracellular hypoxia detection